Neuropathic pain, resulting from damage to the nervous system, is a type of chronic pain that can be difficult to treat. However, hemp flowers, rich in CBD, terpenes and flavonoids, are attracting growing interest as potential therapeutic options in the management of neuropathic pain. In this article, we will explore in detail the mechanisms of action by which CBD and other hemp compounds can reduce these pains, citing scientific studies.
The role of CBD in reducing neuropathic pain:
CBD , or cannabidiol, is a non-psychoactive compound found in hemp flowers. It has been widely studied for its potential analgesic and anti-inflammatory effects. CBD exerts its effects by interacting with multiple targets in the nervous system, including cannabinoid receptors type 1 (CB1) and type 2 (CB2), as well as other receptors and signaling pathways.
Several preclinical and clinical studies suggest that CBD may reduce neuropathic pain by modulating these receptors and regulating inflammatory pathways. For example, a study published in the journal Pain showed that CBD activated vanilloid type 1 (TRPV1) receptors , which inhibited pain transmission in animal models of neuropathic pain.
Additionally, a systematic review and meta-analysis published in the journal Frontiers in Pharmacology analyzed the results of several clinical studies and concluded that CBD was effective in reducing neuropathic pain in patients with various conditions, including diabetic neuropathy. and multiple sclerosis.
The synergistic effect of terpenes in the management of neuropathic pain:
Terpenes , the aromatic compounds found in hemp flowers, may also help reduce neuropathic pain. Certain terpenes, such as limonene , myrcene , and linalool , have demonstrated analgesic and anti-inflammatory properties . They can interact with receptors and pathways involved in pain transmission and inflammation, enhancing the effects of CBD.
A study published in the journal Life Sciences showed that combining CBD with certain terpenes, such as linalool and pinene, produced more pronounced analgesic effects than CBD alone. This synergy between different hemp compounds, known as the entourage effect , can potentially improve the effectiveness of treatments for neuropathic pain.
Flavonoids and their role in the modulation of neuropathic pain:
Flavonoids are phytochemicals found in many plants, including hemp. They are recognized for their antioxidant, anti-inflammatory and neuroprotective properties. Recent studies suggest that certain flavonoids found in hemp flowers may help reduce neuropathic pain.
A study published in the journal Phytotherapy Research examined the effects of a blend of hemp flavonoids on animal models of neuropathic pain. The results showed that flavonoids significantly reduced pain by inhibiting inflammatory pathways and reducing the activation of glial cells, which play a key role in sensitizing neurons to pain.
Additionally, certain hemp flavonoids, such as quercetin and kaempferol , have demonstrated neuroprotective properties by protecting nerve cells from oxidative damage and reducing chronic inflammation associated with neuropathic pain.
Clinical studies on the use of CBD flowers in neuropathic pain:
Although research on the use of hemp flowers for neuropathic pain is still limited, a few clinical studies have been conducted with promising results.
A study published in the European Journal of Pain evaluated the effectiveness of CBD in reducing neuropathic pain in patients with diabetic neuropathy. Participants who received CBD reported a significant reduction in pain compared to the placebo group, with an improvement in quality of life and a reduction in the use of traditional analgesic medications.
Additionally, a study published in the journal Neurotherapeutics examined the use of CBD in patients with neuropathic pain related to multiple sclerosis. The results showed that CBD reduced pain and improved the quality of life of the participants.
To conclude, hemp flowers , rich in CBD, terpenes and flavonoids, offer promising potential in the management of neuropathic pain. CBD acts by modulating the receptors and pathways involved in pain, while terpenes and flavonoids complement its action with their anti-inflammatory and neuroprotective properties. Preliminary clinical studies suggest that the use of hemp flowers may reduce pain and improve quality of life in patients with neuropathic pain. However, more research is needed to better understand the mechanisms of action and determine optimal dosing and treatment protocols.
Choose quality and safety by choosing Maison Sativa for your ORGANIC CBD flowers and oil
CBD flowers from Maison Sativa are an ideal choice due to several key factors. First of all, all Maison Sativa flowers are grown without the use of chemical fertilizers or pesticides . This ensures that the CBD flowers are of premium quality, free from potentially harmful residues.
The use of a vaporizer like the PAX 2 (there are other types of quality vaporizers) is recommended to benefit from the benefits of CBD flowers. Vaporization allows for effective inhalation of CBD without the risks associated with combustion. By vaporizing CBD flowers, you can get rapid relief from neuropathic pain, as the CBD along with terpenes are quickly absorbed by the lungs and enter the bloodstream almost instantly.
However, if you don't want to vaporize, organic CBD oils from Maison Sativa are an excellent alternative . They are full-spectrum , meaning they contain all of the beneficial compounds found in the hemp plant, including other cannabinoids, terpenes, and flavonoids. This full-spectrum composition promotes the entourage effect, where different compounds work together to enhance the therapeutic effects of CBD.
More specifically, ANTALIVA organic CBD oil from Maison Sativa has been specially developed to combat chronic pain, particularly neuropathic pain. It offers a high concentration of CBD and is formulated to maximize its analgesic and anti-inflammatory effects. Regular use of this oil can help alleviate neuropathic pain and improve quality of life.
In summary, CBD flowers from Maison Sativa grown without chemical fertilizers or pesticides offer a high-quality, natural option to combat neuropathic pain. Vaporizing with the PAX 2 vaporizer provides rapid relief without the risks associated with combustion. For those who prefer an alternative to vaporization, organic CBD oils, particularly ANTALIVA oil, offer an effective solution to alleviate chronic pain, including that of neuropathic origin.
It is important to note that neither CBD flowers nor CBD oils are considered medical treatments for neuropathic pain. They may offer symptomatic relief, but are not a substitute for medical consultation. Before starting to take CBD, it is essential to consult a doctor in case of doubt or pre-existing medical conditions.
In this article, we have used information from different scientific sources to support our points. Here is a list of sources we consulted:
Xiong, W., Cui, T., Cheng, K., Yang, F., Chen, SR, Willenbring, D., ... & Zhang, L. (2012). Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. Journal of Experimental Medicine, 209(6), 1121-1134.
Baron, E.P. (2018). Medicinal properties of cannabinoids, terpenes, and flavonoids in cannabis, and benefits in migraine, headache, and pain: an update on current evidence and cannabis science. Headache: The Journal of Head and Face Pain, 58(7), 1139-1186.
Baron, E.P. (2015). Comprehensive review of medicinal marijuana, cannabinoids, and therapeutic implications in medicine and headache: what a long strange trip it's been. Headache: The Journal of Head and Face Pain, 55(6), 885-916.
Maione, S., Piscitelli, F., Gatta, L., Vita, D., De Petrocellis, L., Palazzo, E., ... & Di Marzo, V. (2011). Non‐psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action. British Journal of Pharmacology, 162(3), 584-596.
De Gregorio, D., McLaughlin, RJ, Posa, L., Ochoa-Sanchez, R., Enns, J., Lopez-Canul, M., ... & Gobbi, G. (2019). Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain. Bread, 160(1), 136-150.
Boychuk, D.G., Goddard, G., Mauro, G., & Orellana, M.F. (2015). The effectiveness of cannabinoids in the management of chronic nonmalignant neuropathic pain: a systematic review. Journal of Oral & Facial Pain and Headache, 29(1), 7-14.
Please note that this list is not exhaustive and there are other studies and research available on the subject.