peut-on faire une overdose mortelle de cannabis ?

Fatal cannabis overdose: Myth and reality | House Sativa

Reading time: 6 minutes

1. Introduction (Beginner level)

Cannabis is often associated with heated debates about its safety and health effects. One common concern is the risk of overdose. However, unlike many medications and recreational drugs, a fatal cannabis overdose is extremely rare, if any. In this article, we will explore the scientific reasons behind this claim.

2. Understanding toxicity (Beginner level)

Every substance, from vitamins to medications to street drugs, has a dose that can be fatal. This dose is often measured by the LD50, which is the dose needed to kill 50% of a tested population. Compared to other substances, the LD50 of cannabis is extremely high, meaning one would need to consume an astronomically high amount to reach a potentially lethal dose.

LD50 explanation

3. The endocannabinoid system and CB1 receptors (Expert level)

THC, the main psychoactive compound in cannabis, acts primarily on the CB1 receptors of the endocannabinoid system. These receptors are widely distributed throughout the brain, but are absent from areas of the brainstem responsible for regulating vital functions such as breathing . In comparison, opioids can cause a fatal overdose by affecting the brainstem's ability to regulate breathing. As THC does not have this effect, the risk of death from asphyxiation is zero.

Cannabidiol, more commonly known as CBD, is a non-psychotropic component of cannabis that has gained popularity for its beneficial properties without the side effects associated with THC. Unlike THC, CBD presents no risk of overdose, long-term harmful effects for the body, or risk of mortality.

It is essential to emphasize that at Maison Sativa, we make it a point of honor to guarantee the purity of our products. Whether you opt for our oils or our flowers , rest assured that you benefit only from the benefits of CBD, without a trace of THC.

4. Comparison with other substances (Beginner level)

For comparison, many legal substances, such as alcohol or certain prescription drugs, have a much higher overdose risk than cannabis. For example, consuming only four times the recommended dose of acetaminophen (paracetamol) can lead to fatal liver failure.

overdose of paracetamol equals danger for the liver, fatal risk.

5. The effects of excessive cannabis consumption (Beginner level)

Although a fatal overdose is highly unlikely, excessive consumption of THC-rich cannabis can lead to adverse effects. These effects include paranoia, anxiety, heart palpitations, drowsiness, confusion and disorientation. In most cases, these symptoms go away on their own over time and can be managed with a calm environment and appropriate support.

As for cannabis rich in CBD, it does not cause any of these types of side effects, in fact it does not have any psychotropic effects and does not cause an acceleration of the heart rate.

6. Conclusion (Beginner level)

Science clearly shows that although cannabis can cause unwanted side effects when consumed in excess, the risk of a fatal overdose is almost non-existent. As with any substance, it is essential to use cannabis responsibly and informedly.

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