Cannabidiol , more commonly known as CBD, is a compound naturally found in hemp. In recent years, its popularity has exploded, in part due to its many potential health benefits, including its interactions with the brain. In this article, Maison Sativa explores in depth the effects of CBD on our most complex organ.
The endocannabinoid system: an overview
Before diving into the effects of CBD on the brain, it is essential to understand the role of the endocannabinoid system (ECS). The ECS is a cellular signaling system that plays a crucial role in regulating many bodily functions, including pain, mood, appetite, and sleep. It is made up of receptors found throughout the body, many of which are found in the brain.
How CBD interacts with the brain
Unlike THC, the main psychoactive compound in cannabis, CBD does not induce a "high" effect . But how does this translate to the brain?
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Reduction of anxiety: Several studies suggest that CBD can help reduce anxiety. It appears to modulate brain activity in regions linked to anxiety, such as the amygdala and prefrontal cortex.
- Blessing, EM, Steenkamp, MM, Manzanares, J., & Marmar, CR (2015). Cannabidiol as a potential treatment for anxiety disorders. Neurotherapeutics, 12(4), 825-836.
- Crippa, JA, Zuardi, AW, Garrido, GE, Wichert-Ana, L., Guarnieri, R., Ferrari, L., ... & Busatto, GF (2004). Effects of cannabidiol (CBD) on cerebral regional blood flow. Neuropsychopharmacology, 29(2), 417-426.
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Neuroprotection: CBD has antioxidant properties, which could protect neurons against damage. Additionally, it appears to play a role in neuronal regeneration, particularly in the hippocampus, a region associated with memory and learning.
- Hampson, A.J., Grimaldi, M., Axelrod, J., & Wink, D. (1998). Cannabidiol and (−) Δ9-tetrahydrocannabinol are neuroprotective antioxidants. Proceedings of the National Academy of Sciences, 95(14), 8268-8273.
- Wolf, SA, Bick-Sander, A., Fabel, K., Leal-Galicia, P., Tauber, S., Ramirez-Rodriguez, G., ... & Kempermann, G. (2010). Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis. Cell communication and signaling, 8(1), 1-12.
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Anti-inflammatory effects: Inflammation in the brain can contribute to diseases like Alzheimer's disease. CBD may help reduce this inflammation, offering therapeutic potential.
- Nagarkatti, P., Pandey, R., Rieder, SA, Hegde, VL, & Nagarkatti, M. (2009). Cannabinoids as novel anti-inflammatory drugs. Future medicinal chemistry, 1(7), 1333-1349.
- Aso, E., & Ferrer, I. (2016). Cannabinoids for treatment of Alzheimer's disease: moving toward the clinic. Frontiers in pharmacology, 7, 37.
The potential side effects of CBD
Like any compound, CBD can have side effects. Some users report when consumed in large doses, drowsiness, dizziness, or changes in appetite. It is essential to consult a healthcare professional before starting any CBD treatment.
Conclusion
CBD interacts in complex ways with the brain, providing a range of beneficial potential effects while remaining non-psychoactive. At Maison Sativa , we offer you a range of CBD products, such as our high quality oils, to help you discover its many benefits.
