CBD helps fight sleep disorders
Insomnia is a complex pathology which combines a psychological component and a neurobiological component. This is dissatisfaction with the quantity or quality of sleep associated with at least one of these symptoms: difficulty falling asleep (at least 30 minutes), nocturnal awakenings, waking up too early or inability to go back to sleep. Chronic insomnia is characterized by occurring at least 3 nights per week and for at least 3 months.
We find in these people a degraded quality of life with drowsiness, irritability, difficulty concentrating, etc.
On a molecular level, no neurotransmitter or endogenous molecule seems specifically responsible for the pathophysiology of insomnia. Some studies have highlighted the role of the GABAergic, serotonergic, and cortisol systems , but none are specifically and isolatedly involved in insomnia. Insomnia therefore appears to be a multifactorial pathology. The study of insomnia is also difficult due to the absence of an animal model.
Action of CBD against insomnia
In a study published in 2013, the effect of acute systemic administration of cannabidiol on the sleep-wake cycle was investigated in rats. They randomly administered 2.5 mg/kg, 10 mg/kg, 40 mg/kg of CBD or a placebo to rats. Total sleep percentage increased significantly in the 10 and 40mg/kg CBD groups compared to the placebo group. Sleep latency decreased in the group treated with 10 mg/kg of CBD, but increased in the group given 40 mg/kg. (164)
A recent study explored the effect of CBD in anxiety and sleep. Sleep scores improved within the first month in 67% of patients , but fluctuated over time. (165)
In addition, sleep disorders are often linked to anxiety disorders, CBD also has anxiolytic properties.
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Connections :
71. Inserm. Information files | Inserm - Science for health [Internet]. [cited Oct 30, 2020]. Available at: https://www.inserm.fr/information-en-sante/dossiers-information
164. Chagas MHN, Crippa JAS, Zuardi AW, Hallak JEC, Machado-de-Sousa JP, Hirotsu C, et al. Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats . J Psychopharmacol Oxf Engl. March 2013;27(3):312‐6.
165. Shannon S, Lewis N, Lee H, Hughes S. Cannabidiol in Anxiety and Sleep: A Large Case Series . Perm J. 2019;23:18‐041.